[1] From January through March 2014, he served in the German government as the Coordinator for Transatlantic Cooperation in the Field of Intersocietal Relations, Cultural and Information Policy.

Additionally, Mißfelder was on the German-British Society's Königswinter Conference steering and Executive Committee of the German Council on Foreign Relations (DGAP), among other engagements.

In 2007, he played a key role in forming the CDU's Einstein Connection, an internal group which aims to reinforce conservatism within the party.

[11] The statement led to demands that he resign from party organs and helped launch a debate over the failing German social welfare system.

A similar controversy arose in February 2009 after Mißfelder asserted that a social welfare increase would essentially be a subsidy to the cigarette and liquor industry.

[15] An influential voice on German foreign affairs, Mißfelder had spoken out against the possible entry of Turkey into the European Union but had supported UN actions in Libya, despite strong internal opposition within Germany.

[16] He strongly criticised famed German author Günter Grass when the latter controversially wrote a poem largely interpreted as being critical of Israel.

[20] In May 2014, he made headlines when he was one of few German politicians to take part in a birthday celebration for Schröder in St. Petersburg, at which he spoke with Vladimir Putin, on the height of the Russo-Ukrainian War.