Already as young man he was very interested in literature (his grandmother was the poet Philippine Engelhard).
1836 he met in Berlin Bettina von Arnim; with her he stayed several years in contact.
She made him the main character in her novel Ilius Pamphilius und die Ambrosia.
Ten years later his son, Martin von Nathusius, became his successor.
1861 Nathusius became ennobled, after several years illness he died 1872 during a convalescence in Switzerland.