Her paternal grandmother, Elizabeth Charlotte of the Palatinate was warmly attached to her granddaughter and very devoted to her; she used to visit her almost every day at the Palais-Royal in Paris.

In 1720, King Philip V of Spain wanted to make peace and proposed a triple marriage; his three-year-old daughter, Infanta Mariana Victoria, would marry the fifteen-year-old Louis XV, and his sons, Infante Louis and Infante Charles, would marry two of the Regent's daughters.

Her future husband was expected to become the ruler of Tuscany as his half brother Louis was the heir to the throne of Spain being his father's first son.

She arrived at Buitrago del Lozoya, a day's journey from Madrid; it was there that she met the royal family including King Felipe, Queen Isabel, her sister, the Prince of Asturias and her husband to be, Infante Carlos.

The departure of Philippine was seen as a sad affair, unlike that of her older sister Louise Élisabeth who had never been popular at the court.

The Dowager Queen and Mademoiselle de Beaujolais arrived at the frontier of France at the foot of the Pyrenees mountains at Saint-Jean-Pied-de-Port.

Their mother was obliged to send orders to make a suite of rooms at the Château de Vincennes where they arrived in June.

With the encouragement of the Duchess of Orléans, de Bissy went to Charles himself and asked him his thoughts on a possible re-uniting of the young couple.

The new sovereign Duke said that he had wanted to marry young Philippine and he said to the Parmese minister to use any measure possible to secure his love's hand.