After spending her childhood in Italy, she went to Paris at 16 to study drama against the advice of her parents; her father, actor Philippe Leroy, especially tried to keep her from pursuing a career that followed in his footsteps but was unsuccessful.

After appearing on the stage, Leroy-Beaulieu made her screen début in Roger Vadim's 1983 comedy-drama film Surprise Party.

[3] The success of Coline Serreau's comedy helped her film career and a string of parts in costume films followed such films as Andrzej Wajda's Les Possédés in 1988, Philippe Le Guay's Les Deux Fragonard, and Robert Enrico's and Richard T. Heffron's La Révolution française (Mademoiselle Leroy-Beaulieu acted out the role of Charlotte Corday in the latter production), whose release in 1989 was timed to coincide with celebrations for the bi-centenary of the 1789 Revolution.

[4] The following years, she acted in a various European movies, notable A Soul Split in Two (1993), Neuf mois (1994), Un eroe borghese (1995), Vatel (2000), and Two Brothers (2004).

[5] For the 2002 French presidential election, she publicly expressed her support for Noël Mamère, the candidate of the Green Party in an opinion piece published in the newspaper La Croix.