The polymer version, first introduced in December 2024[3] features the Palawan peacock-pheasant on its obverse side while its reverse side has similar design elements with the cotton-abacá version and it will be in circulation starting December 23, 2024, in limited quantities and in the Greater Manila area.

On the reverse, it now features the Central Bank of the Philippines main office before they were relocated to their current complex in Manila.

The design of the obverse was later revised, the "100" on the lower right corner was moved higher, in turn placed the Central Bank logo below it, the signature of the Central Bank Governor was placed beside the signature of the President of the Philippines, the font for Republika ng Pilipinas and all of the "100" text were also changed and the text Sandaang Piso was made into one line.

The names of the signatories on the bills were later added starting with banknotes featuring the signature of President Joseph Estrada.

On banknotes with the signatures of President Gloria Macapagal Arroyo and BSP Governor Amando Tetangco Jr. from 2005 to 2010, there are two variants where the signatories are wide and narrow.

The wider and lighter version (similar to Arroyo and Rafael Buenaventura signature combination from 2001 to 2004) is used on banknotes issued on 2005 and some in 2008, while the narrower and bolder one is used on notes from 2006 to 2010.

In 2010, the portrait of Manuel A. Roxas was redesigned, a picture of the old Central Bank building and the inauguration of the Republic of the Philippines were added on the lower left corner and bottom center of the bill respectively.

Also, four tactile marks were placed for the elderly and the visually impaired, two pairs on both the extreme left and right side of the front of the note.