At South High School, Lindsay elected to wear the same jersey number as his father, 22.

[5] Playing for the Rebels, he chased the Denver Public School District record for rushing yards (4,400), which was set by his father in 1979.

[6] After a successful first three years of high school, Lindsay committed to playing for the University of Colorado Boulder.

[7] Shortly after surpassing his father's rushing record during his senior season, Lindsay suffered a severe ACL tear that brought an end to his high school career.

[8] Despite this injury, Mike MacIntyre, Colorado's coach, upheld the school's scholarship offer for the 2013 season.

[18] During the 2017 regular season, he ranked ninth among all Football Bowl Subdivision players with 1,474 rushing yards.

He was selected as a semifinalist for the Doak Walker Award for the nation's top running back.

3 running back on the depth chart behind third-round rookie Royce Freeman and veteran Devontae Booker.

[29] In Week 11, in a 23–22 victory over the Los Angeles Chargers, Lindsay recorded his first multi-rushing touchdown game.

He was named to the Pro Football Writers of America All-Rookie Team, becoming the fourth Broncos running back to receive this award, joining Bobby Humphrey (1989), Terrell Davis (1995), and Olandis Gary (1999).

[41] In Week 1 against the Tennessee Titans, Lindsay rushed for 24 yards before exiting the game with a toe injury.

[46] The Broncos placed a right of first refusal (RFR) restricted free agent tender on Lindsay on March 16, 2021.

[49] He entered the 2021 season as the third running back on the depth chart behind Mark Ingram II and David Johnson.

[54][55] He was elevated to the active roster on October 6 for the Colts' Week 5 game against the Broncos due to an injury to starting running back Jonathan Taylor.

[57] He was then released from the Colts' practice squad on November 10, to make room for Jake Funk.