[2][3][4] Her performance was captured in the Disney+ live stage recording of Hamilton which was released in 2020 for which she earned a nomination for the Primetime Emmy Award for Outstanding Supporting Actress in a Limited Series or Movie.

Soo's other Broadway credits include the title role in Amélie (2017), Rebecca in The Parisian Woman (2017–18), Cinderella in Into the Woods (2022), and Guenevere in Camelot (2023).

[10] Soo played the titular character in the pre-Broadway engagement of Amélie at the Ahmanson Theatre in Los Angeles from December 2016 to January 2017.

Soo reprised her role when Amélie began preview performances on Broadway at the Walter Kerr Theatre on March 9, 2017, opening officially on April 3.

Entertainment Weekly declared, "Soo, best known for originating the role of Eliza Schuyler in Hamilton, grounds the story with her poignant voice, infusing Inez Milholland with emotion and vulnerability so striking, you're reminded of why she's so closely associated with another woman who wrote herself into the narrative.

[16] Soo starred opposite Sara Bareilles, Brian D'Arcy James, Gavin Creel, Joshua Henry, Patina Miller, and Cheyenne Jackson.

The cast included Soo's husband, Steven Pasquale, as well as James Monroe Iglehart, Jessie Mueller, Rachel Dratch, and Kevin Chamberlin.

[20] In The New York Times article on the Best Theatre of 2022, Scott Heller praised Soo as "a gift to the musical theater" and that in that year she "showed more sides to her talent than ever".

[21] On November 1, 2022 it was announced Soo would star as Guenevere in the Broadway revival of Camelot opposite Andrew Burnap, and Jordan Donica.

The production debuted in March 2023 at the Vivian Beaumont Theatre at Lincoln Center with Bartlett Sher as director and Aaron Sorkin with a revised book.

[26] In 2021, she received a Primetime Emmy Award for Outstanding Supporting Actress in a Limited Series or Movie nomination for her performance in the Disney+ live stage recording of Hamilton which was released in 2020.

According to Soo, the core mission of "The Eliza Project" is "to use the arts as a means of expression, as an outlet for personal experience, and to uplift the creative spirit.