Philoxenus Anicetus (Greek: Φιλόξενος ὁ Ἀνίκητος; epithet means "the Invincible") was an Indo-Greek king who ruled in the region spanning the Paropamisade to Punjab.

Historians have not yet connected Philoxenus with any dynasty, but he could have been the father of the princess Kalliope, who was married to the king Hermaeus.

Philoxenus struck several series of bilingual Indian silver coins, with a reverse of a mounted king, a type previously used as obverse by Antimachus II sixty years earlier and as reverse on rare types of Nicias.

Philoxenus means "lover of foreigners" or "hospitable" in Greek, and considering that his drachms were square, a feature that was rare among Indo-Greeks but standard for Sakas, this shows that Philoxenus had good connection and relations with the nomads that had conquered Bactria.

Philoxenus also minted some Attic-type tetradrachms (with Greek legend only), meant for circulation in Bactria.