Pho Prathap Chang (Thai: โพธิ์ประทับช้าง, pronounced [pʰōː prā.tʰáp t͡ɕʰáːŋ]) is a district (amphoe) in the western part of Phichit province, central Thailand.

The government split off some parts of Mueang Phichit and Pho Thale Districts and formed the new Pho Prathap Chang minor district (king amphoe) on 24 June 1967.

The district was named after the temple (Wat) Pho Prathap Chang, which was built by King Suea (Tiger King, Sanpet VIII, Suriyenthrathibodi) of Ayutthaya at his birthplace.

Neighboring districts are (from the north clockwise) Sam Ngam, Mueang Phichit, Taphan Hin, Bueng Na Rang of Phichit Province and Bueng Samakkhi of Kamphaeng Phet province.

The district is divided into seven sub-districts (tambon), which are further subdivided into 99 villages (muban).