As well as being the home of the Phoenix Symphony, Arizona Opera and Ballet Arizona, it is also the site for Broadway touring companies, a variety of dance productions, and appearances by popular entertainers, as well as the location for business seminars, and convention general sessions.

In June 2004, a $18.5 million renovation took place, in conjunction with the construction of the neighboring Phoenix Convention Center West Building.

Reconfigured main-floor cross aisles, additional elevators and a new wheelchair seating section, greatly improve accessibility for patrons with disabilities and updates compliance with the Americans with Disabilities Act.

There is a 60-foot × 100-foot (18.29m × 30.48m) stage area, high technology acoustical, lighting, rigging and sound systems, a Green Room, rehearsal hall and star, chorus and musicians dressing rooms.

Eastwood's bus crashes onto the steps of Symphony Hall at the climax of the movie.