Pickens is a town in Holmes County, Mississippi, United States.

[4] On May 9, 1919, an African American veteran was lynched as part of the Red Summer of 1919 because of an “improper note” written to a white woman.

[5] Pickens is located in the southeast corner of Holmes County at 32°53′12″N 89°58′12″W / 32.88667°N 89.97000°W / 32.88667; -89.97000 (32.886672, -89.970092),[6] on the west side of the Big Black River.

Mississippi Highway 17 follows US 51 through Pickens, but leaves the highway south of town to lead southeast 13 miles (21 km) to Camden, and splits from US 51 north of Pickens to lead north 18 miles (29 km) to Lexington, the Holmes County seat.

Mississippi Highway 432 leads west from Pickens 18 miles (29 km) to Benton.

The town of Pickens is served by the Holmes County School District.