Pickstown is a town in southern Charles Mix County, South Dakota, United States.

Pick, former director of the Missouri River Office of the United States Army Corps of Engineers.

Pickstown began as a government town for U.S. Army Corps of Engineers employees building and then operating nearby Fort Randall Dam.

United States Air Force officers and airmen arrived in the 1950s to operate a Strategic Air Command radar base built on a hill three miles east of town, locally known as "Radar Hill".

Currently, the "Fort Randall Casino and Hotel" owned and operated by the Yankton Sioux Tribe is located at the abandoned radar base.

Pickstown is located adjacent to the east side of the Fort Randall Dam on the Missouri River.

According to the United States Census Bureau, the town has a total area of 0.65 square miles (1.68 km2), all land.

The racial makeup of the town was 82.6% White, 10.4% Native American, 0.5% Asian, and 6.5% from two or more races.

The racial makeup of the town was 85.12% White, 11.31% Native American, 0.60% Asian, and 2.98% from two or more races.