Pickwick Mill was listed on the National Register of Historic Places in 1970 for having state-level significance in the themes of agriculture, architecture, and industry.

[2] It was nominated for being one of southeast Minnesota's oldest surviving water-powered mills, serving as a key local industry in its day and a Winona County landmark to the present.

[3] Pickwick Mill was built on the banks of Big Trout Creek by Thomas Grant and Wilson Davis.

[2][6] The property's National Register nomination says it was built in 1854 as a grist- and lumber mill and converted to flour production in 1856.

[6] During the American Civil War the mill ran non-stop, churning out 100 barrels of flour a day for the Union Army.