Pickwick Lake has excellent sportfishing areas, including the Wilson Dam tailwater at the upper end of the reservoir, noted for record-size smallmouth bass and catfish.

Another favorite spot is the discharge basin at Colbert Fossil Plant west of Sheffield, Alabama, where the warm water discharged from the power plant attracts fish during cold weather.

Pickwick Lake is the north end of the Tennessee-Tombigbee Waterway, which provides a water transportation route to the Gulf of Mexico.

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