Picloram is a systemic herbicide used for general woody plant control.

[3] A chlorinated derivative of picolinic acid, picloram is in the pyridine family of herbicides.

[4] During the Vietnam War, picloram and other herbicides were combined to make Agent White (commercially available as Tordon 101) and enhanced Agent Orange, which was previously conducted by the British military during the Malayan Emergency.

Large quantities of these herbicides were sprayed by U.S. forces in areas where they considered its long-term persistence desirable, such as inland forests.

[3] No history of human intoxication by picloram has been documented, so symptoms of acute exposure are difficult to characterize.