[3] A special feature is the intrinsic create, read, update, and delete (CRUD) functioning.

Persistent symbols are first-class citizens (objects), they are loaded from database files automatically when accessed, and written back when modified.

[citation needed] The design of PicoLisp is most similar to the first version of MacLisp, Interlisp and mainly Portable Standard Lisp.

In 2009, the 64-bit version was released, another rewrite, this time written in generic assembly, which in turn is implemented in PicoLisp.

[6] In July 2015, Burger announced PilOS - The PicoLisp Operating System, a minimal prototype based on the modification of PilMCU targeting embedded applications.

[7] It runs on standard x86-64 PC hardware, directly off the BIOS and includes all the features of 64-bit PicoLisp (minus native function calls, due to the fact there is no other native environment such as the C standard library); in principle, it works as its own operating system.