It was released in June 2007 as the first single from their debut album, Poison Kiss (2007).

The song peaked at number 70 on the US Billboard Hot 100 chart and became a top-three hit in Australia and the Czech Republic.

The song is certified platinum in Australia for shipping over 70,000 copies.

"Pictures of You" was supported in a promo video directed by Marc Klasfeld.

The same music video was being used by ABC Television and the Seven Network to promote the second season of Brothers & Sisters, but with scenes from the show mixed in.