[1] The Domesday Book records that by 1086 Judith, Countess of Huntingdon, a niece of William I of England held the manor.

[1] In 1152 Simon II de Senlis inherited Piddington and almost immediately granted it to the Priory of St Frideswide, Oxford.

[1] In 1153 Simon II died, and his heir King Malcolm IV of Scotland, confirmed the grant of Piddington to the Priory.

[1] In about 1174 Henry II deprived William of all his titles and lands in England and granted the Earldom of Huntingdon to Simon III de Senlis.

[1] After Aubrey's death the Crown held Piddington in escheat for several years before it passed to his heir, Reynold de Dammartin.

[1] In the Anglo-French War of 1202–14 Reynold supported Philip II of France against King John, for which he was deprived of his English estates.

In 1326 Despenser was executed for rebelling against Edward II and forfeited his estates, but de Hadlow was allowed to keep Piddington until he died in 1346.

[1] Title was then disputed between the Sutton and de Peyto families, but in 1359 the Priory finally succeeded in regaining the manor.

By 1152 "Ralph the hermit" had established Holy Cross chapel on Muswell Hill about 1 mile (1.6 km) south of the village.

[6] Llewellins and James of Bristol[5] cast the treble, second and third bells in 1887,[6] the year of Queen Victoria's Golden Jubilee.

In about 1910, the Great Western Railway built a new main line linking Ashendon Junction and King's Sutton to complete a new high-speed route between its termini at London Paddington and Birmingham Snow Hill.

The GWR opened a railway station called Brill and Ludgershall just over 1 mile (1.6 km) east of Piddington.

It connects with the Varsity Line just west of Bicester, runs through the villages of Ambrosden and Arncott and terminates at Piddington, serving various military depots en route.

John Drinkwater (June 1, 1882– March 25, 1937) who became one of the Dymock poets and a playwright working with the Birmingham Repertory Theatre, is buried in St Nicholas' churchyard.

Flora Thompson's (née Timms) ancestors the Shaws and the Wallingtons, yeoman farmers, lived in Piddington and are buried outside the porch of the church.

Flora Thompson's paternal grandmother Martha Wallington (1816-1888) was born in the old farmhouse now a private house at the junction with Widnell Lane.