Pier Luigi Carafa (Senior) (18 July 1581, Naples, Italy – 15 February 1655, Rome, during the conclave) was a cardinal of the Catholic Church, and a member of the Roman Curia.

[1][2] He was bishop of Tricarico and nuntius of Cologne.

On 2 June 1624, he was consecrated bishop by Cosimo de Torres, Cardinal-Priest of San Pancrazio, with Giovanni Antonio Angrisani, Archbishop of Sorrento, and Alessandro Suardi, Bishop of Lucera, serving as co-consecrators.

[1] He was made cardinal in March 1645 by Pope Innocent X.

He died during the 1655 papal conclave.