He made 25 total appearances for Bayern and won a variety of domestic and international tournaments, also having loans at fellow league teams FC Augsburg and Schalke 04.

[6] Højbjerg joined Bayern in July 2012[7] and, at the age of 17 years and 251 days,[8] made his professional debut on 13 April 2013[8] in the Bundesliga against 1.

FC Nürnberg,[9] as a substitute for Xherdan Shaqiri[9] and thus became the youngest player ever to play for the Bayern Munich first team in the Bundesliga.

[10] In December of that year, he was in the Bayern squad which won the 2013 FIFA Club World Cup in Morocco, although he did not enter the field of play during the tournament.

[14] His first match of the 2014–15 season was the DFL-Supercup on 13 August, playing the first hour and then being substituted for Mario Götze, as Bayern lost 2–0 at Borussia Dortmund.

[22] He played 30 games for the Gelsenkirchen-based club, including six in the Europa League, and at the end of the season he told Danish newspaper B.T.

[24] He made his debut in the Premier League on 13 August as the season began with a 1–1 home draw with Watford, coming on in the 55th minute in place of James Ward-Prowse.

[29] On 11 August 2020, Højbjerg joined Tottenham Hotspur on a five-year deal, for a reported initial fee of £15 million plus add-ons.

[32] Despite this early setback, Højbjerg soon became a key member of José Mourinho's squad in the central defensive midfield position, earning wide praise for his performance in many games,[33][34][35][36] as well as receiving a nomination as Premier League Player of the Month for November.

[39] On 1 November 2022, he scored a goal in the 95th minute in a 2–1 away win over Marseille, in which Tottenham Hotspur finished top of Group D in the 2022–23 Champions League season.

[43] On his third cap on 7 September 2014 he scored his first international goal, equalising as Denmark began their UEFA Euro 2016 qualification campaign with a 2–1 win over Armenia in Copenhagen.

[47] In their opening match, a 1–0 loss to Finland, he missed a penalty; the game had been stopped and resumed due to Christian Eriksen's medical emergency.