Hupé studied sciences at the Universities of Strasbourg and Nancy, where he graduated in 1931 with the geneticist Lucien Cuénot.
During World War II he was an artillery officer and received the Croix de Guerre.
He is also known for his work on the trilobites of the Lower Cambrian of Morocco, and his detailed stratigraphy, commissioned by the Service Geologique du Maroc in 1952.
He gained international recognition with his monograph of the Lower and Middle Cambrian and Ordovician in southern Morocco, and received in 1957 the Charles Doolittle Walcott Medal.
He left his trilobites collection to the University of Rennes I, and to the Natural History Museum in Havre.