Pierrefitte-Nestalas is a commune in the Hautes-Pyrénées department in south-western France.

Pierrefitte-Nestalas is in the southern part of the Lavedan valley in the central French Pyrenees mountains.

It is a necessary point of passage to gain access to either Cauterets or to the Pays Toy and Gavarnie beyond.

The hamlet of Nestalas, with its medieval church, was a point along the ancient road leading from the Abbey of Saint-Savin up the Gave de Gavarnie to the thermal site of Luz-Saint-Sauveur.

Thanks to hydro power, industrial activities such as chemical manufacturing, aluminum smelting and power generation were developed in Pierrefitte-Nestalas and the adjacent town of Soulom during the course of the twentieth century.