[4] Piers Morgan Live was broadcast primarily from CNN's studios[5] at the Time Warner Center in New York City.

[8] Because of major news events, such as Arab Spring of 2010s and the Great East Japan earthquake, tsunami, and nuclear disaster, the ratio of taped to live interviews was the opposite of his expectations.

[citation needed] The show received its second largest audience on February 28, 2011, as 1.346 million people tuned in to see Morgan interview actor Charlie Sheen, whose recent abnormal behavior made headlines.

Piers Morgan Tonight also had fewer total viewers that month than Larry King Live did a year before, 620,000 versus 635,000.

[19] On February 23, 2014, CNN announced that Piers Morgan Live would be cancelled, with its final episode scheduled to air some time in March of the same year.

[20][21] The series aired its final episode on March 28, 2014; most of the broadcast consisted of coverage of the disappearance of Malaysia Airlines Flight 370.

Morgan’s interviews with various pro-gun activists in the wake of the Sandy Hook shooting led to a “Deport Piers Morgan” petition being launched on the White House website, which received enough signatures to receive a response from the Obama administration, where they did not deport him, citing First Amendment rights.

[32] The Huffington Post reported, "before the interview was scheduled, it was made clear that Grammer would answer all questions, including those about [his ex-wife].