Pietà Hotspurs had their league debut on 23 October 1934, but any success the club had hoped to achieve was postponed due to the outbreak of World War II.

After the war's end, Pietà took part in the Anglo Maltese Football League, before joining the Third Division of the National Championships, where they spent ten seasons.

The team won the league and promotion, but spent ten years in the Third Division.

[1] The club's football nursery has acquired a fame of producing talented footballers such as Cleavon Frendo, Massimo Grima, Valeri Bojinov, Saviour Darmanin and Attila Filkor, as well as Jovica Milijić, a Maltese futsal player of Serbian descent.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.