The Pietà for Vittoria Colonna is a black chalk drawing on cardboard (28.9×18.9 cm) attributed to Michelangelo Buonarroti, dated to about 1538–1544 and kept at the Isabella Stewart Gardner Museum in Boston.

It has at any rate proved influential: There are several copies by students of lesser skill in Florence and Rome, a reworking by Ludovico Buti and an adaptation by Lavinia Fontana.

[1] In 2007, the Milanese restaurator and art historian Antonio Forcellino announced that an oil painting of the same subject had been discovered in a private home in Rochester, New York.

Above the two stands a beam, the Cross, on which is inscribed, vertically, a quotation by Dante: Non vi si pensa quanto sangue costa – "There they don't think of how much blood it costs".

Both belonged to Roman groups that focused on achieving salvation by faith through prayerful contemplation of sacred history, as does their poetry of this period.