Pieterzijl (Dutch: [ˈpitərˌzɛil]; Gronings: Pieterziel; West Frisian: Pitersyl) is a village in the municipality of Westerkwartier in the province of Groningen in the Netherlands.

In 1440, monks from the Jerusalem monastery in Gerkesklooster built a zijl (= lock), which served as a discharge sluice for the new Zijldiep, a canalized connection in the Lauwers, the old course of which runs around the village along the hamlet of De Leegte [nl].

After 1580, the former monastery property with the associated heerlijkheid was seized by the province of Friesland, which from then on held sway over Visvliet and Pieterzijl.

In 1637, the manor and inheritance of Visvliet were sold to the region of Stad en Lande [nl].

In 2008, the current (regular) campsite De Blauwe Reiger ('The Blue Heron') was established there.

However, this was not favored by the local grietman and the classis of the Dutch Reformed Church, who soon had the vermaanhuis closed again.

The following year they broke with the tradition of praying alone in silence and the preacher started saying the prayer aloud.

In the early 1880s, however, the problem arose that preachers no longer wanted to come to the village, which was then difficult to reach.

The newer primary school merged with that of Visvliet in 1983 and has since been converted into village hall De Wending ('The Twist').

At the southern end of the village, at Pieterzijlsterweg 5, was the monumental head-neck-rump farm De Peterswarf with coach house and barns from about 1875.