In this period Genoa lost Pera in Turkey, Caffa in Crimea and Chios in Greece, while the flourishing trade with those regions declined.

In 1458, after turmoil with Turk and Aragonese soldiers, and with the Ghibelline faction in Genoa, Pietro asked King Charles VII of France for help.

After a vain attempt at insurrection against the French, Pietro was stoned by the populace near the Porta Soprana on 14 September 1459.

Pietro di Campofregoso is played by Ali Ersin Yenar in 2012 film Fetih 1453.

In the film, Pietro, not mentioned by name, orders Giovanni Giustiniani (Cengiz Coşkun) to command Genoese army to help Byzantine Empire preparing for war against the Ottoman Empire after an assault towards a Genoese freight by the Turks in the Bosphorus.