Pike Creek is a census-designated place (CDP) in New Castle County, Delaware, United States and is part of the Philadelphia-Camden-Wilmington, PA-NJ-DE-MD Metropolitan statistical area.

In 2007, CNN's Money Magazine ranked Pike Creek number 1 on its list of the 100 Best Places to Live in the United States.

Pike Creek is approximately five miles from downtown Newark, which contains the University of Delaware.

Pike Creek is connected to the University of Delaware campus and the Newark downtown area by several bike trails.

Pike Creek is approximately 10 miles west of the state's largest city, Wilmington, which is a national financial center.

[4] According to the United States Census Bureau, the CDP has a total area of 6.1 square miles (16 km2), all land.

[17] In the season 5 premiere "Sympathy for the Devil" of the CW show Supernatural, Pike Creek is where Lucifer convinces his temporary vessel Nick to allow his possession.

On August 5, 2021, the Delaware Supreme Court upheld the prior decision from 2010 not to designate the 130 acres as open space, reducing the amount of potential homes from 224 to 60.