Piketon is the location of the Pike County Fairgrounds and is served by the Scioto Valley School District.

Around 1824, Lucas built a large brick house two miles east of Piketon, named Friendly Grove, which became a center of local political activity.

[4] The initial operation of the lead cascade of the American Centrifuge Demonstration Facility in Piketon, Ohio, in 2005 by Centrus Energy Corp. comprised the first publicly visible component of next-generation uranium enrichment technology in the United States that employed a gas centrifuge process rather than gaseous diffusion to produce enriched uranium.

[5] Piketon was expected to exhibit a growth economy during the early 21st century with the establishment of a full-size commercial uranium enrichment plant by 2012.

[10] The Pike County Dogwood Festival is hosted annually in Piketon on the last full weekend in April.

The festival was started in 1971, and features local foods, crafts, live bluegrass music and a parade, including a performance by the Piketon High School marching band.

Several other exhibits from various local groups are also hosted in the Piketon Jasper United Methodist Church, including the Pike County Historical Society, the Pike County Quilters, Appalachian Kitchen, and artworks by local students.

[11][12] Piketon is briefly shown in the 2013 American action film, White House Down, directed by Roland Emmerich.

Towards the climax of the film, there is a scene in which terrorists hack into NORAD and launch a missile at Air Force One from the Portsmouth Gaseous Diffusion Plant located in Piketon, killing everyone on board.