Piketoprofen (INN; trade names Calmatel, Picalm) is a nonsteroidal anti-inflammatory drug (NSAID) for topical use in form of a cream.

[1][2] Chemically, it is the 4-picolineamide of the NSAID ketoprofen.

Thionyl chloride reacts with ketoprofen to form its acid chloride (2).

Amide formation with 2-amino-4-methylpyridine (3) gives piketoprofen.

[3][4] This drug article relating to the musculoskeletal system is a stub.