The National Shrine and Parish of San Antonio de Padua, commonly known as the Church of Pila, is a Roman Catholic national shrine dedicated to Saint Anthony of Padua in the Philippines in 1578 and the first Antonine parish church in the Philippines in 1581 and probably in Asia.

[3][5] They started to establish "Villa de Pila" and soon built a church out of cane, dedicated to Saint Anthony of Padua.

It survived British invaders in 1762 when the people of Pila submerged it in Laguna de Bay facing the church.

Due to flooding in Pagalangan (today's Victoria), the church and rectory were demolished and transferred to their current site in Sta.

The bell tower was reconstructed by Damaso Bolanos and finished by Francisco de Santa Olalia, and again rebuilt by Lope Toledo.

[9] The present rectory or convent (casa parroquial) is made of stone, constructed under the direction of Benito del Quintanar in the 1840s.

[6] Fray Benito also started the Archicofradía del Nuestro Señor Padre San Francisco which was next in rank to the Venerable Orden Tercera (VOT) of the Franciscan Order.

In 1855, plans for a concrete belfry were drawn by the local architect and builder Maestro Sebastián Bade and was built after the 1863 earthquake.

From being a calm town, Pila including the parish was rent asunder from 1896 during the Spanish revolution until the American occupation in 1902, where attempts of take over and reorganization of the government happened.

The first monument to the Sacred Heart of Jesus in the province of Laguna was inaugurated at the Pila Plaza during the town fiesta in 1922.

[14] The church of Pila was featured on The Amazing Race Asia 2 in 2007 and in the daytime television drama of ABS-CBN Be Careful with my Heart.