Pileru is a census town in Annamayya district of Rayalaseema region of the Indian state of Andhra Pradesh.

Pileru is located 197 Km North East of Bangalore, The Capital City Of Karnataka and 189 Km North West of Chennai, The Capital City Of Tamil Nadu and 464 Km South To The State Capital Amaravati .It is the mandal headquarters of Pileru mandal in Rayachoti revenue division.

It is located at an average elevation of 458 m (1,502 ft) above mean sea level.

Pileru is located at the center Spot where the Annamayya, Chittoor and Tirupati districts share their borders.

Pileru serves as a bus depot headquarter of the Pileru region and the Bus services are provided by state corporations APSRTC (Andhra Pradesh), and KSRTC(Karnataka).