[1] A purpose-built facility designed by William Henry Wheeler was built in Bath Gardens between 1874 and 1875.

Phase 1 involved 115 in-patient beds, the outpatients, a single-storey A&E and X-ray, and Physical Medicine.

The five-storey 72-bed maternity department would be built in this phase, but would be initially part of outpatients, until the whole hospital had been later completed.

The former maternity unit was at Boston General and Wyberton West (owned by the county council) hospitals.

[9] Work on phase 1, undertaken by Shepherd Building Group and due to cost £2.25m, began in August 1967.

[12] The inauguration of construction work was performed on 11 June 1968, by the Earl of Ancaster, with four hundred guests.

[13][14] The ceremony was attended by the architect, George Grenfell-Baines, and the Bishop of Grantham, Ross Hook, who gave a prayer.

[5] Some 400 friction piles, driven 30 feet deep, were used for the construction of the main ten-storey block.

[31][32] The new facility was officially opened by Princess Anne on 23 June 1977, arriving by helicopter at 2.15pm at Boston High School.

[35][36] On 25 April 1989, Birgitte, Duchess of Gloucester opened the Phase 3 development, travelling to Boston with the Queen's Flight.

[40] The £2.1 million medical education centre was built in late 1992 by Lindum Construction (for the Trent Regional Health Authority).

[42] The Prince of Wales visited the hospital on 17 March 1992, having earlier opened the Waterside Centre in Lincoln, flying in by helicopter.

Cofely (part of GDF Suez) installed a 526 kWe engine-based CHP, supplied by GE Jenbacher.

Just north of the building there is a helicopter landing pad, used by the Lincolnshire & Nottinghamshire Air Ambulance.

[61] The Care Quality Commission raised concerns about the treatment of children in the emergency department, and about the early detection of critically ill patients.