The Pill Hill Historic District is a historic district roughly bounded by Boylston Street, Pond Ave., and Acron, Oakland and Highland Roads in Brookline, Massachusetts.

The district, which is mainly residential, was developed in the mid-19th century for an upper-middle class professional population.

Several major Boston architects designed homes in the district, including Robert Swain Peabody, Walter H. Kilham, Ware & Van Brunt, and William Ralph Emerson.

Dr. Walter Channing, one of the doctors living in the district, established one of Boston's earliest women's hospitals; his efforts inspired Brookline's Free Hospital for Women, which moved to Pill Hill in 1895.

This article about a National Register of Historic Places listing in Norfolk County, Massachusetts is a stub.