Presenters usually participate in different aspects of regional life, such as attending a traditional wedding or visiting a mining community.

They address the viewer directly, acting as tourists-turned-tour guides, but are also filmed interacting with locals and discovering interesting locations in (mostly) unrehearsed sequences.

Globe Trekker also sometimes includes brief interviews with backpackers who share tips on independent travel in that particular country or city.

Specifically, the crew consists of a camera operator and a sound technician, plus a producer and a director, who scout locations two weeks before filming.

Most of the music is written for the show by Ian Ritchie, Michael Conn, Colin Winston-Fletcher, with additional music from Makoto Sakamoto, Nainita Desai & Malcolm Laws, Nomad, Jesper Mattsson, The Insects, The West India Company, Stephen Luscombe, and Pandit Dinesh.