Pilot Knob is a city in northeast Iron County, Missouri, United States.

[6] A post office called Pilot Knob has been in operation since 1858.

[7] The Battle of Pilot Knob in the fall of 1864 was a notable clash in the area during the Civil War.

Pilot Knob is located on Missouri Route 21 approximately one and a half miles (2.4 km) north-northeast of Ironton and three miles (5 km) southeast of Elephant Rocks State Park.

There were 392 housing units at an average density of 440.4 per square mile (170.0/km2).

35.8% of all households were made up of individuals, and 16.7% had someone living alone who was 65 years of age or older.

28.6% of all households were made up of individuals, and 8.8% had someone living alone who was 65 years of age or older.