The Pilsbury Block is an historic commercial building at 200-210 Lisbon Street in Lewiston, Maine.

The block was built in 1870, and is a late example of Italianate architecture, exhibiting some Romanesque details.

It is a three-story masonry structure with a narrow rounded bay at the street corner.

The ground floor storefronts are set in groups of segmented-arch or flat-topped segments of stone, with either display windows or entrances topped by transom windows.

[2] The oldest portion of the building, the corner section, was built in 1870 for George H. Pilsbury by Jesse T. Stevens, a local engineer.