This Venetian complex is composed of two distinct buildings, a historical palazzo built along the Grand Canal during the 18th century, and an old theater in ruins, the Teatrino.

[2] A year after the Palazzo Grassi opening, the Venice city council organized a competition to convert the 16th century custom house Punta della Dogana into a contemporary art museum.

[6][7] In April 2016, François Pinault and the Council of Paris announced plans to convert the city's landmark building Bourse de Commerce into a contemporary art museum.

He teamed up with Pierre-Antoine Gatier (architect-in-chief of the French National Heritage), as well as Lucy Niney and Thibault Marca of NeM agency, and Setec Bâtiment for the engineering of the project.

[17] The Pinault Collection artist-in-residence program was set up in 2015 in Lens, a former mining city in the North of France where the Louvre opened a local branch known as the Louvre-Lens.

The Pinault Collection awards yearly one outstanding book on modern and contemporary art history with 10 000 euros.

[49] As of 2019, the collection contained 5,000 pieces of 20th and 21st century artists, including works from Willem de Kooning, Piet Mondrian, Agnes Martin, Mark Rothko, Richard Serra, Damien Hirst, Takashi Murakami, Jeff Koons, Cy Twombly, and Cindy Sherman.