The Pindaré rises in the low hills which separate its basin from that of the Tocantins River to the south.

It is a left tributary of the Mearim River, which it joins not far from that river's mouth in the Baía de São Marcos.

The Serra do Tiracambu lies to the west, and separates the basin of the Pindaré from that of the Gurupí River.

Part of the river's basin lies in the 271,197 hectares (670,140 acres) Gurupi Biological Reserve, a full protected conservation unit created in 1988.

This article related to a river in Maranhão, Brazil is a stub.