Webb attended high school at Colegio San Agustin where she was batchmates with Kris Aquino and Karen Davila.

During her career at ABS-CBN, Webb was a first news anchor of ANC Primetime News (1999–2004) and Dateline Philippines (2004–2014) and also host of Umagang Kay Ganda, XXX: Exklusibong, Explosibong, Exposé (from 2008 until the show ended) and TV Patrol Weekend.

[5] On September 26, 2016, Webb named as a host for a new current affairs daily program titled The Source.

[6] In July 2024, Webb joined Bilyonaryo News Channel, along with her former ABS-CBN and CNN Philippines personalities.

[7] She anchors the network's flagship newscast Agenda together with veteran broadcast journalist Korina Sanchez.