As an actress, Piper is best known for playing Nancy Patanski on the Nickelodeon drama series Deadtime Stories.

"[7] In 2007, at 7 years old, Reese began hosting Piper's Picks TV in Wellington, Florida and became the youngest video podcaster on the Internet.

Along the way, Piper began hosting InsPIPERation, a blog-style series in which Reese answers questions and gives advice to viewers and provides behind the scenes information.

In 2017, Piper hosted a Delta Airlines project aimed at introducing its Aircraft Maintenance Technician vocation to middle school students throughout the United States.

[24][25] Piper also made a guest star appearance in the Nickelodeon comedy series AwesomenessTV as hot dog cart operator Dot Hart.

[28] The film is written by Paul James Houghton and inspired by real events about a lonely and insecure high school girl, trying to navigate her way through the dark shadows of her depression and anxiety brought on by severe bullying, cyberbullying and deception.