[3] A new 197,000-square-foot (18,300 m2) facility, which houses grades 5–12 and the school district administration, was opened in January 2003 at the cost of $22.3 million.

PSEO classes can be taken by qualifying students at Minnesota West Community & Technical College, which has a campus in Pipestone.

Academic extracurricular activities of notable mention include Math Team, Knowledge Bowl, Marching band, Student Council, Peer Helping, One Act Play, Drama, Speech, FFA, among others.

In 2007, the Pipestone Area girls' basketball team defeated the Albany Huskies, 50-49, at the Target Center in Minneapolis, Minnesota, to win its first Minnesota State High School League state championship in school history.

Each year, the Pipestone Area football team plays nearby Luverne in a rivalry dating back to 1957.