The Pira Paraná River is a river of the Vaupés Department, Colombia.

It is a left-bank tributary of the Apaporis River.

People of the Eastern Tucano language group live along the river.

[1] The main figure of the "Rock of Nyi", a group of several rocks with some petroglyphs standing near by the Equator, got a graffiti in the 1970s by a Protestant missionary.

[2]