The railway from Piraeus to Patras was a 230-kilometre long metre-gauge railway line in Greece that connected the port of Athens, Piraeus with Patras in the Peloponnese peninsula, via Athens "Peloponnese" central station and Corinth.

Formerly one of the main lines of the Greek railway network, it has now largely fallen into disuse.

It has mostly been replaced by the Athens Airport–Patras railway, a new standard-gauge line whose first section opened in 2004 and which remains under construction between Aigio and Patras.

The 13 km section between Piraeus and Agioi Anargyroi, a northern suburb of Athens, has since been removed and replaced by the corresponding section of the upgraded Piraeus–Platy railway.

The final section of Line 1, between Patras and Agios Andreas, and the entirety of Line 2, between Agios Andreas and Kato Achaia, operate on the adjacent Patras–Kyparissia railway.