Piramo e Tisbe is an opera in two acts, described by its composer as an intermezzo tragico, by Johann Adolf Hasse to a libretto by Marco Coltellini.

Piramo e Tisbe is based on the story of the lovers Pyramus and Thisbe as told in Ovid's Metamorphoses.

The same story is parodied in Shakespeare's Midsummer Night's Dream, and this comic version of it forms the basis of the 1745 opera Pyramus and Thisbe by John Frederick Lampe, but Coltellini's libretto is a straightforward sentimental tragedy, in which the two eponymous lovers kill themselves, (as does Tisbe's father, who blames himself, having previously forbidden their love).

Piramo e Tisbe is more elaborately composed than Hasse's other operas, with accompanied recitatives and arias which are thorough-composed, that is, not merely strophic settings.

The work was revised and performed at the theatre of the Laxenburg Palace of that city in September 1770.