The municipality contains part of the 1,592,550 hectares (3,935,300 acres) Serra da Ibiapaba Environmental Protection Area, created in 1996.

The city origin comes from ingrown land in a place called "Botica" issued to Antonio Fernandes Macedo on January 20, 1777.

Its foundation goes back to an unknown date of the year 1844, when its owner, Father Domingos de Freitas e Silva, came seeking refuge, after fighting for independence of Piauí, built a house in a place called Anajás, and then, next, a chapel dedicated to Our Lady of Remedies, which is the current patron of the city.

On August 16, 1870, the Piripiri district is elevated to parish with its borders established and attached to the municipality of Piracuruca.

In 1910, it was opened the Palacete do Conselho da Vila (Palace of the Village Council), building which was built in 1909.