The Piscataquis River (/pɪˈskætəkwɪs/) is a major tributary of the Penobscot River, found in Piscataquis County, Maine, United States.

It starts from the confluence of its East Branch and West Branch (45°16′54″N 69°35′24″W / 45.2817°N 69.5901°W / 45.2817; -69.5901 (Piscataquis River source)) in Blanchard.

The river flows in a mostly eastern direction until it meets the Penobscot at Howland.

[2] The Appalachian Trail runs along the West Branch of the Piscataquis, crossing the East Branch just upstream from their joining.

This article related to a river in Maine is a stub.