Piscobalaena is an extinct genus of cetaceans, which lived from the Middle to Late Miocene epochs (about 11.6 to 5.3 million years ago) in Peru and Florida.

Piscobalaena is considered a representative of Cetotheriidae a group of baleen whales with primitive characteristics similar to that of Balaenoptera, fossil species of which have been found mainly in the northern hemisphere.

[citation needed] Other fragmentary remains attributed to Piscobalaena are also from Peru, but date a little older (late Miocene, about 10 million years ago).

This could have been because the Isthmus of Panama was open until at least Late Pliocene, allowing the passage of marine species from the Atlantic to the Pacific and vice versa.

Other marine mammals found in the Pisco Formation include the odd dolphin Odobenocetops, the long-necked seal Acrophoca, and aquatic sloth Thalassocnus.