El Mariel, Pitbull's second studio album, was released on October 30, 2006, and spawned four singles: "Bojangles", "Ay Chico (Lengua Afuera)", a remix of "Dime", and "Be Quiet".

"I Know You Want Me (Calle Ocho)" became Pitbull's breakout into international success, peaking at number two on the Billboard Hot 100 and reaching the top ten in several European territories.

"Guantanamera (She's Hot)" would be reissued nearly fifteen years later on Trackhouse (Daytona 500 Edition) given a spike in popularity as a result of a TikTok trend.

The album was preceded by two singles, the international hits "Hey Baby (Drop It to the Floor)", which peaked at No.

The Pitbull song "Back in Time" was released in 2012 as the lead single from the soundtrack to the film Men in Black 3, peaking at No.

His seventh studio album, Global Warming, was released on November 16, 2012, and produced the hit singles "Get It Started", "Don't Stop the Party", and "Feel This Moment".

The album also features the lead single from the 2014 animated film, Penguins of Madagascar, titled "Celebrate".

Pitbull's fourth compilation album, Greatest Hits, was released on December 1, 2017, and features two new recordings.

Pitbull released his first full-length soundtrack album for the film Gotti alongside Jorge Gómez on June 16, 2018.

The album includes the RIAA Latin 9× Platinum hit single "No Lo Trates" featuring Daddy Yankee and Natti Natasha.

Pitbull's first EP in over ten years (2013's Meltdown), it features new collaborations with Tim McGraw and Dolly Parton and brings back Vikina and Nile Rogers for new tracks.