The street is named after William Pitt the Younger,[1][2][3][4][5] prime minister of the United Kingdom, and before Acts of Union 1800, of Great Britain.

It hosts several prominent sites including Kwong Wah Hospital[6][7][8][9][10][11] and the headquarters of Chinese YMCA of Hong Kong.

[17][11] The ventilation shaft of the station behind Exit A1, with its practical appearance, was the landmark of the street facing Nathan Road.

[12] The latest reconstruction of Kwong Wah Hospital relocated Emergency Department, together with its entrance, from Waterloo Road to Pitt Street in 2023.

[24] This location was considered situating in Mong Kok Tsui for exact and Yau Ma Tei, formerly written as Yaumati, for large area in this period.

[28] The Public Works began to build Yaumati Disinfecting Station with quarters for inspector on Pitt Street, which remained unnamed, in 1904 and completed it in 1905, handing over to Sanitary Board in April.

[29] In 1912 report, the Public Works laid a 9" earthenware pipe sewer in Pitt Street and Waterloo Road from opposite the Yaumati Disinfecting Station to take the drainage from the new Sanitary Department Stables.

In response to the proposal, the government offered the location of Yaumati Disinfecting Station and provided initial funds for five years in 1907.

The Governor Sir Frederick Lugard, opened the hospital on 9 October 1911, reported in The China Mail.

[34] In 1925 report, the street extended west to the Kwong Wah Hospital on Kowloon Inland Lot 1213.

[35] In 1926, New block of Kwong Wah Hospital was built on Kowloon Inland Lot 1213 on the street.

Another reconstruction of Kwong Wah Hospital relocated Emergency Department, together with its entrance, from Waterloo Road to Pitt Street in 2023.

In 1923, the Public Works Department issued a tender to construct a pier for dust shoot at the end of the street.

The school was later moved Nelson Street and finally settled at current premises on 56 Waterloo Road.

In 1928 the association began to build a hostel and hall on Kowloon Inland Lot 1483, on Waterloo Road and Pitt Street, and the construction was completed in 1929.

In 1966, the headquarters moved into here and new building was erected, with a programme centre, a gymnasium and YMCA International House.

The restaurant closed after 27 years in 2005, with 200 workers losing their jobs, and only the Mong Kok one remains open.

The floors of the restaurant once was converted to a shopping centre, first Mk1 Super Digital Mall, selling digital products, then MediLink Square, selling medical products, and later MediLink Square was occupied by a spa and sauna, Windsor Spa.

In 1994, the restaurant was rebuilt as Tung Nam Commercial Centre, a twenty-three storey office building.

In 1954, Kam Wah Theatre, a theatre-cinema with 2180 seats, commenced at southwest corner of the junction with Canton Road on 21 December, which operated till 21 September 1970.

The theatre, of modern appearance with green and buff in colour, was designed by Iu Tak Lam.

Chinese communists in Hong Kong, encouraged by Cultural Revolution and 12-3 incident, fought against British colonial rule with homemade bombs, real or fake.

A squad of policemen followed the couple secretly, caught them and seized the bomb at the junction with Shanghai Street.

[94][95] On 11 November 1946, a woman living on second floor of 45 Pitt Street was robbed and murdered by several robbers.

Robbed properties of gold and cash, were worth three hundred and sixty Hong Kong dollars at that time.

Except on the west side of Nathan Road, MTR ventilation shaft and exit occupied part of the street.

[105] Yau Tsim Mong District Council had proposed the a subway to link Yau Ma Tei station and Kwong Wah hospital, the Highways Department considered the proposal infeasible as it required reconstruction of the ventilation duct of tunnel and station, and closure of Exit A2 and two lanes of Nathan Road for more than two years.

The school building is a multi-storey building, occupying east, north and west side, with open area facing Pitt Street.Tung Wah Museum, at the centre of Kwong Wah Hospital, is a museum of traditional Chinese architecture of 1911.

Inside, it divided into many small units, featuring with toy stores, especially LEGO minifigures,[113] also vintage collectibles.

[114] The shopping centre turns active around six to seven o'clock in the evening when the business owners come after office.